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1. Edlund H:Transcribing pancreas. Diabetes 1998, 47:1817–1823.

2. Jonas JC, Sharma A, Hasenkamp W, et al.: Chronic hyperglycemia triggers loss of pancreatic beta cell differentiation in an animal model of diabetes. J Biol Chem 1999, 274(20):14112–14121.

3. Weir GC, Laybutt DR, Kaneto H, et al.: Beta-cell adaptation and decompensation during the progression of diabetes. Diabetes 200I, 50(Suppl 1):S154–S159.

4. Bonner-Weir S, Orci L: New perspectives on the microvasculature of the islets of Langerhans in the rat. Diabetes 1982, 31:883–939.

5. Weir GC, Bonner-Weir S: Islets of Langerhans: the puzzle of intraislet interactions and their relevance to diabetes. J Clin Invest 1990, 85:983–987.

6. Orci L:The insulin factory: a tour of the plant surroundings and a visit to the assembly line. Diabetologia 1985, 28:528–546.

7. Guest PC, Bailyes EM, Rutherford NG, Hutton JC: Insulin secretory granule biogenesis. Biochem J 1991, 274:73–78.

8. Bonner-Weir S, Baxter LA, Schuppin GT, Smith FE:A second pathway for regeneration of the adult exocrine and endocrine pancreas: a possible recapitulation of embryonic development. Diabetes 1993, 42:1715–1720.

9. Finegood DT, Scaglia L, Bonner-Weir S: (Perspective) Dynamics of B-cell mass in the growing rat pancreas: estimation with a simple mathematical model. Diabetes 1995, 44:249–256.

10. Olbrot M, Rud J, Moss LG, Sharma A: Identification of beta-cell specific insulin gene transcription factor RIPE3b1 as a mammalian MafA. Proc Natl Acad Sci USA 2001. (In press.)

11. Sander M, German MS:The b-cell transcription factors and development of the pancreas. J Mol Med 1997, 75:327–340.

12. Rhodes CJ: Processing of the insulin molecule. In Diabetes Mellitus. Edited by LeRoith D,Taylor SI, Olefsky JM. Philadelphia: Lippincott-Raven; 1996:27–41.

13. Rhodes CJ,Alarcon C:What b-cell defect could lead to hyperproinsulinemia in NIDDM: Some clues from recent advances made in understanding the proinsulin conversion mechanism. Diabetes 1994, 43:511–517.

14. Easom RA: CaM kinase II: a protein kinase with extraordinary talents germane to insulin exocytosis. Diabetes 1999, 48(4):675–684.

15. Leahy JL, Cooper HE, Deal DA, Weir GC: Chronic hyperglycemia is associated with impaired glucose influence on insulin secretion: a study in normal rats using chronic in vivo glucose infusions. J Clin Invest 1986, 77:908–915.

16. Meglasson MD, Matschinsky FM: New perspectives on pancreatic islet glucokinase. Am J Physiol 1984, 246:E1–E13.

17. Henquin JC:Triggering and amplifying pathways of regulation of insulin secretion by glucose. Diabetes 2000, 49(11):1751–1760.

18. Weir GC, Bonner-Weir S: Insulin secretion in type 2 diabetes. InDiabetes Mellitus: A Fundamental and Clinical Text, edn 2. Edited by LeRoithD,Taylor SI, Olefsky JM. Philadelphia: Lippincott Williams & Wilkins;2000:595–604.

19. Eto K,Tsubamoto Y,Terauchi Y, et al.: Role of NADH shuttle system inglucose-induced activation of mitochondrial metabolism and insulinsecretion. Science 1999, 283:981–985.

20. Atwater I, Mears D, Rojas E: Electrophysiology of the pancreatic b-cell. In Diabetes Mellitus. Edited by LeRoith D,Taylor SI, Olefsky JM. Philadelphia: Lippincott-Raven; 1996:78–102.

21. Gilon P, Shepherd RM Henquin JC: Oscillations of secretion driven by oscillations of cytoplasmic Ca2 as evidenced in single pancreatic islets. J Biol Chem 1993, 268:22265–22268.

22. Prentki M, Corkey BE:Are the b-cell signaling molecules malonyl-CoAand cytosolic long-chain acyl-CoA implicated in multiple tissue defectsof obesity and NIDDM? Diabetes 1996, 45:273–283.

23. Porksen N, Munn S, Steers J, et al.: Effects of glucose ingestion versus infusion on pulsatile insulin secretion. Diabetes 1996, 45:1317–1323.

24. McGarry JD Dobbins RL: Fatty acids, lipotoxicity and insulin secretion. Diabetolgia 1999, 42:128–138.

25. Brunzell JD, Robertson RP, Lerner RL, et al.: Relationships between fasting plasma glucose levels and insulin secretion during intravenous glucose tolerance tests. J Clin Endocrinol Metab 1976, 42:222–229.

26. Ward WK, Beard JC, Halter JB, et al.: Pathophysiology of insulin secretion in non–insulin-dependent diabetes mellitus. Diabetes Care 1984, 7:491–502.

27. Ward WK, Bolgiano DC, McKnight B, et al.: Diminished b-cell secretorycapacity in patients with noninsulin-dependent diabetes mellitus. J Clin Invest 1984, 74:1318–1328.

28. DeFronzo RA, Ferrannini E, Simonson DC: Fasting hyperglycemia in noninsulin-dependent diabetes mellitus: contributions of excessive hepatic glucose production and impaired tissue glucose uptake. Metabolism 1989, 38:387–395.

29. Mitrakou A, Kelley D, Mokan M, et al.: Role of suppression of glucoseproduction and diminished early insulin release in impaired glucosetolerance. N Engl J Med 1992, 326:22–29.

30. Kahn SE,Andrikopoulos S,Verchere CB: Islet amyloid:A long-recognized but underappreciated pathological feature of type 2 diabetes. Diabetes 1999, 48:241–253.

31. Lorenzo A, Bronwyn R,Weir GC,Yankner BA: Pancreatic islet cell toxicityof amylin associated with type 2 diabetes mellitus. Nature 1994,368:756–760.

32. Tokuyama Y, Sturis J, Depaoli AM, et al.: Evolution of b-cell dysfunction in the male Zucker diabetic fatty rat. Diabetes 1995, 44:1447–1457.

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